Cost-Effectiveness Analysis of Certain Foreign and Local Brands of Antimicrobial drugs in Yemeni Market

Abstract

Background: Pharmacoeconomic is an economic evaluation of pharmaceuticals in which the cost-effective analysis is one of the most important types of them that compares the relative costs and outcomes (effects) of different courses of action. Objective: The study aimed to Cost-Effectiveness analysis of some local and foreign antibacterial brands in Yemeni market. Method: Cost-effective analysis (CEA) was performed for four different antibacterial types (Azithromycin, Ciprofloxacin, Doxycycline and Amoxiclav), and there were four brands from each type that were of different origin, this analysis was carried out by antibacterial test for all brands against two types of sensitive bacteria (Staph. Aureus and E. coli) and analysis of the efficacy of antibacterial brands in comparing to the cost or prices of this brands to calculate the cost-effective ratio (CER) and select the best that was the lower value. Results: In the present study, from the pharmacoeconomic analysis, the Yemeni brands were the best in three types (Azithromycin, Doxycycline and Amoxiclav) with the smallest CER that were 40, 4.5, 32.11 in case of Staph. aureus and 13.33, 23.68 ,0 in case of E. coli respectively, while the Indian brand was the best in one type (Ciprofloxacin) with the smallest CER that were 8.13 in case of Staph. aureus and 6.4 in case of E. coli respectively, the four brands of amoxiclav type were showed ineffective against E. coli in comparing to standard that was effective against E. coli. Conclusion: This study was concluded the best brands to be selected was Yemeni brand in three antimicrobials (Azithromycin, Doxycycline and Amoxiclav) with 75% and the Indian brand in one type (Ciprofloxacin) with 25%. All the amoxiclav brands of different country were ineffective against E. coli.