Influence of Zn2+ Ions Doping on the Antibacterial Activity of Barium-Nickel Ferrite Nanoparticles‏

Abstract

The nanoparticle ferrites (NPFs) materials have recently attracted more attention. Due to their intriguing characteristics and wide variety of medical applications as an anticancer, antifungal, and antibacterial activity. In the current work, Zn doped barium-nickel ferrite with composition BaNi2-xZnxFe16O27 (x=0.0, 0.4, 0.8, 1.2, 1.6, and 2) was synthesized for antibacterial activity using a ceramic technique. BNZF  powder ferrite  was characterized by X-ray diffraction. The Debye-Scherer formula has been used to calculate the average crystallite size from 43 to 56 nm. The small crystallite size and the higher surface area of nanoparticles ferrite can enhance antimicrobial activity, causing an improvement in surface reactivity. Also, a higher ROS value generally depends on a larger surface area, and crystallite size.  The sample prepared  were investigated for their antibacterial activity against gram-negative bacterium Escherichia coli, and gram-positive bacteria  Staphylococcus aurous using the agar well diffusion method. The antibacterial activity of the zinc doped barium nickel nanoferrites powder  on both gram-negative bacteria  and  gram-positive bacteria was acceptable. The antibacterial results of the barium-nickel ferrites doped zinc nanoparticle on bacteria activity showed that the nanoparticles shows an inhibitory growth on gram-positive Staphylococcus aurous and gram -negative Escherichia coli with high antibacterial effect on Staphylococcus aurous of 21 mm diameter of inhibition zone. Hence, the developed barium nickel ferrites doped by zinc nanoparticle shows high antibacterial effect on (Staphylococcus aurous) and Escherichia coli which makes it a potential material for biomedical application.