Investigating Caralluma penicillata's Medicinal Properties: Effects on Haematological Parameters and Renal Functions in Cotton Pellet Induced Granuloma in Adult Guinea Pigs

Abstract

Background: Caralluma penicillata is a plant that possessing a great therapeutic potential in Yemeni folk medicines, such as antipyretic, antirheumatic, for the treatment of peptic ulcer and antihyperglycemic. Aim: The study was conducted to determine the impact of C. penicillata on a few haematological variables and tow aspects of renal functioning in cotton pellet-induced granuloma in adult male guinea pigs. Method: Thirty six guinea pigs were assigned randomly to six groups (I, II, III, IV, V and VI), each with six guinea pigs. Group (I) A normal control group got 5% Polysorbate 80 in dosages similar to those of the drugs. Group (II) Normal saline in an equivalent dosage was given to the untreated control group. Groups (III-VI) got tested drugs either singly or in combinations. Results: According to the findings, C. penicillata extract did not appear to reduce the increases in total leukocytic count, haematocrit value, or erythrocytic sedimentation rate. An increase in neutrophils, monocytes, and eosinophils was seen, along with a noticeably less number of lymphocytic cells. An increase in plasma urea and creatinine indicated a significant deterioration in renal functioning, according to the data. This nephrotoxic effect was unaffected by C. penicillata extract or indomethacin, either alone or in combination. Conclusion: The C. penicillata extract was unable to reverse the hematological or nephrotoxic consequences of cotton pellet-induced granuloma.