Antihypercholesterolemia Activities by Functional Effects of Some Mix Plant Seeds in Rats

  • Mohammed Sadeg A. Al-Awar Al-Razi University and Amran University
  • Mohammed Abdullah Y. Al-Eryani Amran University
  • Adel Ahmed A. Muaqeb Aden University
Keywords: Hypercholesterolemia, lipid profile, flax seed, sunflower seed and pumpkin seed


Background: The moderated effect of flax, sunflower and pumpkin seeds are common used as edible seeds in human nutrition. Aim: To investigate the nutritional effect of flax/sunflower/pumpkin mix seeds on hypercholesterolemia for male albino rats by estimated biological, biochemical and histopathological examinations.  Methods: The study focused on flax/sunflower/pumpkin seeds mix powder on rat suffered from hypercholesterolemia. The feed intake, body weight gain, feed efficiency ratio, relative liver and heart weight, lipid profile, liver enzymes, kidney function, oxidative stress markers, lipid peroxide levels and heart histopathology for normal and hypercholesterolemic rats were examined. Main first group (6 rats) was fed on basal diet for 12 weeks. Main second group (24 rats) fed on diet with hypercholesterolemia for 8 weeks, then diet supplemented with mix seeds powder 3, 6 and 9%, respectively for successive 4 weeks. Results: The results clearly demonstrate that dietary treatment with mix flax /sunflower /pumpkin seeds (30 g; 60 g and 90 g) for 4 weeks has a powerful modulating effect to improve biological evaluation, serum blood levels and heart tissues changes of hypercholesterolemic rats then, this mix seeds have the potential in reducing cardiovascular diseases complications due to hypercholesterolemia. Conclusion: Flax/sunflower/pumpkin mix seeds have modulation effect of biochemical analysis levels and improve heart tissues changes of rats. Hens, human beings can use flax/sunflower/pumpkin mix seeds to increment high levels of lipid blood levels, liver enzymes, kidney function and enhance heart tissues by their high nutritional content values and functional effects.

Author Biographies

Mohammed Sadeg A. Al-Awar, Al-Razi University and Amran University

Department of Medical Laboratory, College of Medical Sciences, Al-Razi University.

Department of Biology, Faculty of Applied Science, Amran University,

Mohammed Abdullah Y. Al-Eryani, Amran University

Department of Biology, Faculty of Applied Science, Amran University, 3Department of Biology, Faculty of Science

Adel Ahmed A. Muaqeb, Aden University

Department of Biology, Faculty of Science , Aden University